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This protective effect was primarily driven by a 30% reduction in liver decompensation events, comprising ascites, hepatic encephalopathy, variceal bleeding, and hepatorenal syndrome (IRR: 0.70, 95%CI: 0.52-0.94, P = 0.020), based on six studies comprising 877,488 participants

It was engineered by Eli Lilly to bind both receptors with carefully calibrated affinities

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This longer half-life results both from endosomal recycling mediated by the neonatal Fc receptor, and from stabilization of the N- and C-termini of the FGF21 moiety

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