Brain insulin resistance may indeed play a role in the pathophysiology of cognitive disorders, and addressing this may be a mechanism through which GLP-1RAs act pro-cognitively 35
GLP-1 and its agonists bind to receptors in the pancreas, activating them to secrete insulin after you eat
However, if they stop slowly, and have expanded their awareness and understanding of healthy lifestyle behaviours and eating habits, their hunger and satiety will be more manageable, making it easier for them to maintain a healthy weight. Mr Winnett adds that in his own practice, he has commonly seen patients maintain their weight long-term after tapering off semaglutide
It is not appropriate for everyone and should only be used under proper supervision
You may only see an additional 1% to 2% weight loss over what you achieved at 10mg, with noticeably stronger side effects
If you are managing conditions like diabetes, proper dosing becomes even more critical