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TRIUMPH Phase 3 Retatrutide Trials (NCT05929014 and related)
The proposed mechanisms include weight loss itself, improved insulin signaling, lower systemic inflammation, and possibly direct effects on GLP-1 receptors expressed by some cancer cells
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doi: 10.1007/s12161-023-02565-7 95 AshrafGJDasPSahuRNandiGPaulPDuaTK
This could also propose a change in the study design of preclinical and clinical trials that would take into consideration the specific heterogeneity of the pathological pathways and specific characteristics of the patients and thus give more reliable results for the studied drugs
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