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Primary outcome: Percentage change in body weight and the proportion of participants who lost at least 5% of baseline weight by week 68 Results: Primary outcome (% weight loss): Wegovy - 16%, Placebo - 5.7% (p 35 - 68.9% Randomized treatment groups Group 1 (374 patients): Tirzepatide titrated to the maximum tolerated dose of 10 mg or 15 mg once weekly Group 2 (376 patients): Semaglutide titrated to the maximum tolerated dose of 1.7 mg or 2.4 mg once weekly Tirzepatide was initiated at a dose of 2.5 mg once weekly, and the dose was increased by 2.5 mg every 4 weeks until a maximum tolerated dose of 10 mg or 15 mg was reached
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Implications for Clinical Practice: GLP-1s as Adjuncts to Diet and Exercise Commonly reported side effects of GLP-1 medications include gastrointestinal events such as bloating, nausea, vomiting, and diarrhea
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2003, Neumann et al
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