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Additionally, a study by Alkabbani et al

the combination's evidence is theoretical

For example, biased GLP-1R signalling is observed following stimulation with exendin-phe1, which carries a phenylalanine substitution at position 1 of exendin-4, causing a similar reduction in receptor internalisation and increased plasma membrane recycling to GLP-1R V229A (60)

PYCARD, PYD And CARD Domain Containing

de Oliveira AlmeidaGNienktterTFBalieiroCCAPasqualottoECintraJBCarvalhoHCPet alCardiovascular benefits of GLP-1 receptor agonists in patients living with obesity or overweight: a meta-analysis of randomized controlled trials

According to Bessette and Timothy S