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29,54 The STEP-HFpEF trial reported a reduction in systolic BP by an average of 4.9 mmHg in the semaglutide group, compared to a reduction of 2.0 mmHg in the placebo group, in a mean difference of 2.9 mmHg

In spite of their limitations, these studies are the first to demonstrate a capacity of exogenously administered NAC to reach the CNS

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