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After initial repletion, a maintenance dose is given, often 1,000 mcg intramuscularly every month or every 2 to 3 months, to prevent recurrence of deficiency

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The rhabdomyosarcoma frequently develops in the infancy

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Mitochondrial dysfunction and systemic inflammation impair muscular oxygen utilisation and extend the inflammatory recovery phase following physical exertion

Methodological heterogeneity further complicates interpretation across studies