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The distinction matters because the solution is straightforward: maintain adequate hydration, especially during periods of gastrointestinal distress

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This resulted in recurrent emesis and low appetite, with a consequent 45-kilogram (100 lbs) weight loss from a baseline of 158.8 kg (350 lbs), and a seven-point reduction in glycated hemoglobin from a baseline of 14% over the course of ten weeks

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