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Weight loss likely plays a major role by reducing inflammation

In the present study, we extend these findings by showing livers from GCLM KO mice exhibit a persistently greater level of oxidant stress as measured by protein carbonylation and expression of redox-sensitive genes

The data showed dose-response relationships for both the benefits and the side effects (i.e., the higher the dose, the higher the efficacy and the greater the rate of bothersome side effects)

Figure 3 Targeted next-generation sequencing (NGS) using a customized hybrid-capture panel covering all coding regions as well as selected intronic and promoter regions of 130 genes [as described by Sahm et al

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suggests these actions might involve the activation of hormone-sensitive lipase (HSL), an enzyme critical for hydrolyzing stored triglycerides into free fatty acids and glycerol, possibly mitigating adipocyte size