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NAD+ precursors (like NR or NMN) supply substrate to raise NAD+ directly, whereas 5-Amino-1MQ works upstream by blocking NNMT, an enzyme that drains the methylation/SAM pool and is implicated in NAD+ salvage dynamics in fat

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According to the authors of a 2022 review on the subject, the mode of action is similar to biologics.3 In other words, they mimic the native chemicals on which theyre based