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186,187,509,510 The accumulated DNA oxidative damage in AD hyper-activates the DNA damage sensor PARP-1, thereby reducing the concentration of cellular NAD + and suppressing the function of NAD + -SIRT1-PGC-1 axis, which in turn causes abnormal mitochondria
doi:10.1186/s12970-020-00377-2
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Diarrhea is the most frequently observed gastrointestinal symptom among COVID-19 patients
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Alternatives, such as small molecules or smaller peptides that could be taken orally would significantly simplify the treatment regimen for people with type 2 diabetes
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