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Mechanistically, macrophage-specific inhibition of GLUL leads to accumulation of succinate and HIF-1 via glutamine-dependent -aminobutyric acid (GABA) shunting (thereby inhibiting vessel sprouting and metastasis) and via stimulation of T effector cells

doi: 10.1016/j.ejphar.2015.09.029 67 PajaresMRojo AIMandaGBoscLCuadradoA

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This is the recommended volume for a 5mg vial because it produces a concentration of 2.5 mg/mL, which translates to clean, whole-number dosing on a U-100 syringe

In this way, the process of glucuronic acid conjugation dominates [13]

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