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Recent research has shown that hyperglycemia induced cellular stress, such as ERS (120) and oxidative stress (119), which stimulate the pyroptotic process in renal cells, and various signaling pathways, such as TLRs/NF-B/NLRP3 inflammasome signalling pathway, TXNIP/NLRP3 inflammasome pathway, ATP/P2X purinergic signalling pathway, and MAPKs/NLRP3 inflammasome signalling pathway (119, 121)

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Approximately 50 percent of these genes are modulated toward a younger, healthier expression pattern (Pickart et al., 2018)

This effect was reportedly greater than the results observed when either GHK-Cu or HA was studied independently

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