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Discontinuation should be considered if erythema, irritation, or pigmentary changes develop

BBB dysfunction is considered a key mechanism through which peripheral inflammation contributes to CNS pathology in ASD, allowing inflammatory molecules and immune cells to infiltrate neural tissue and exacerbate neuroinflammation (Galea, 2021)

doi: 10.1089/ars.2017.7115 28 RennerNSchbFPapeRSuciuISprengASckertAKet al

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Microbial selenium metabolism: a brief history, biogeochemistry and ecophysiology