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The pancreatic-endocrine-osseous axis involves a potential link between DPP-4, bone, and energy metabolism through the receptor activator of nuclear factor kappa B ligand (RANKL), which induces DPP-4 expression in osteoclasts, leading to decreased GLP-1 levels and increased blood glucose levels
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Expected Results: What the Research Shows According to multiple clinical studies, tirzepatide has demonstrated superior weight loss outcomes compared to GLP-1-only medications
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** Based on the treatment policy estimand: treatment effect regardless of if patients stayed on treatment or took other weight loss therapies
(2022) 107:e1339e47
