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This is a common question from some patients, so we actually devoted a whole blog post on this topic here: Are Ketamine Infusions Addictive

The thrifty gene hypothesis gained traction in that environment

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J Immunol 183 : 46014608 Fitzpatrick AM, Holguin F, Teague WG, Brown LA 2008 Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma