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Aminoglycosides (e.g., gentamicin, amikacin, kanamycin, tobramycin) chelate iron in cochlear tissues, generating ROS that leads to oxidative stress, mitochondrial dysfunction, and programmed cell death

Delivery method and clinical oversight matter for both effectiveness and safety

6 Emerging clinical applications 6.1 Non-alcoholic steatohepatitis (NASH)/non-alcoholic fatty liver disease (NAFLD) Studies investigating GLP-1 receptor agonists for the prevention of NAFLD/NASH indicate potential effectiveness via several molecular mechanisms

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