The most common adverse events reported by those on tirzepatide compared with placebo, respectively, were diarrhea (18.4% vs 6.3%), nausea (17.0% vs 6.5%), and constipation (14.8% vs 6%)
Certain genetic predispositions may suggest a longer titration window or different initial expectations, but lifestyle, comorbidities, and adherence remain the strongest drivers of actual weight-loss timelines
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This difference by type 2 diabetes status reflects the fact that approved doses differ for chronic weight management versus treatment of type 2 diabetes, where doses for type 2 diabetes can typically start off lower and only increase if deemed necessary