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Participants who had received the placebo up to week 80, achieved an average of 19.2% reduction in body weight at 104 weeks after switching to the maximum tolerated dose of retatrutide
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Slides were washed with PBS-Tween, then incubated with secondary antibodies donkey anti-rabbit IgG (H+L) highly cross-absorbed Alexa Fluor Plus 647 (A32795, 1:500), donkey anti-rat IgG (H+L) highly cross-absorbed Alexa Fluor Plus 647 (A48272, 1:500), and donkey anti-goat IgG (H+L) cross-absorbed Alexa Fluor 555 (A-21432, 1:500) for 45 minutes at room temperature
Representative photomicrographs of immunohistochemical staining for Cas-3, NF-B, and AMH in ovarian sections from control, GSH, Mel, CARB, GSH+CARB, and Mel+CARB groups
Notably, liraglutide (LEADER trial) and semaglutide (SUSTAIN-6 trial) have demonstrated cardiovascular benefits, including reductions in cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke
