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Researchers monitoring GI adverse events should collect data on meal patterns to differentiate compound-related GI effects from dietary confounders, particularly during the first 812 weeks of dose escalation when GI adverse events are most frequent
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Electrospray ionization in positive mode and multiple reaction monitoring are applied for detection
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The water amount changes the concentration and syringe units, so it must be recorded with the vial size
It has different solubility and acid-base properties under different pH conditions
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