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GHK-Cu activates TGF-beta pathways in fibroblast studies and upregulates collagen I and III synthesis at nanomolar concentrations in vitro, but this has not been fully replicated in large human RCTs
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Simultaneously, the peptide inhibits enzymes involved in lipogenesis, reducing the conversion of excess calories into stored fat
Tuxhorn JA, McAlhany SJ, Dang TD, Ayala GE, Rowley DR
PMID: 1522753
Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases
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