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Cardiometabolic outcomes have taken center stage, with clinical trials tracking secondary and composite endpoints beyond weight loss

However, in a recent placebo-controlled crossover study to evaluate the effects of liraglutide in subjects with T2DM and coronary artery disease undergoing dobutamine stress echocardiography (DSE), liraglutide did not improve the systolic function of the left ventricle during DSE or patients exercise capacity [46]