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Body fat distribution changes differ, with men seeing more concentrated midsection reduction and women experiencing more distributed fat loss

Prebiotic fibers (inulin, psyllium) can amplify probiotic benefit by feeding beneficial bacteria, though introduce fiber gradually on semaglutide to avoid excessive bloating

doi:10.1111/bph.15638 Walker EG, Lo KR, Pahl MC, et al

A separate study on liraglutide - an earlier GLP-1 medication - found that it actually increased bone formation by 16% and reduced total bone mineral content loss compared to a control group during a weight maintenance phase after caloric restriction

GLP-1 medications work with hormone pathways involved in appetite regulation, digestion and metabolic processes

Others may experience constipation or fatigue, especially as the body adjusts to the medication