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Shyamali Dharmage who provided guidance for interpretation of the included studies and provided comments on the manuscript

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It could be because youre exercising more, or dietary changes mean you're consuming less water overall

Tirzepatide doesn't require separation from most medications, but because it slows stomach emptying, some oral medications may absorb more slowly

We strongly prefer the transdermal route (patches or gels) over oral pills, as this avoids the first-pass effect in the liver and is associated with a lower risk of blood clots (VTE)