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Risk factors for epididymitis in pre-pubertal boys include recent urinary tract surgery or instrumentation procedures and anatomic abnormalities, such as posterior urethral valves or meatal stenosis, whereas risk factor in post-pubertal up to transition age include sexual activity, strenuous physical activity, bicycle or motorcycle riding, and prolonged periods of sitting, and epididymitis is most commonly caused by sexually transmitted infection by Neisseria Gonorrhoeae or Chlamydia Trachomatis [251, 252]

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Both cI and cII are implicated as apoptotic sensors via different mechanisms

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10.1152/ajpcell.2001.281.2.C388 35

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