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Using fluorescence-activated nuclei sorting to enrich for non-neuronal cells, we generated a dataset of 109,334 non-neuronal (1,722 unique genes, 3,216 unique transcripts) and 103,607 neuronal cells (3,987 unique genes, 13,696 unique transcripts

Switching was defined as a change to a different GLP-1 between consecutive months (e.g., January to February 2025)

The SURMOUNT trials demonstrated significant weight loss advantages at this dose level

Avoid metabolic enzyme inducers drugs like rifampin may reduce effectiveness by speeding up drug clearance

They can also start right away with simple changes that better serve this growing populationno menu overhaul required