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Of note, the prevalence of HF varied across these trials from 9% to 24%, and HF events were considered a secondary endpoint
The numbers do not add up
New-onset bloody diarrhea, severe abdominal pain, fever, or significant changes in bowel patterns should prompt evaluation for UC flare rather than being attributed solely to medication side effects
Design Randomised, double-blind, placebo-controlled - people were assigned by chance, neither side knew who got what, and one group got an inactive look-alike
Most women find their effective dose between 7.5 mg and 12.5 mg
B12 injection shots can usually be felt within 24 hours (and a change should show in blood tests after a month or two) A high dose of B12 oral supplementation takes the same time as an injection: roughly 24 hours to feel an improvement and then up to 2 months to show in blood markers
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