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These adverse effects include nausea, vomiting, anaphylactoid reactions, bronchospasm, hypotension (Ershad et al
Its unclear what causes them, but overexertion and heat prompt them
doi: 10.1021/acscentsci.9b01063 112 McNeillECrabtreeMJSahgalNPatelJChuaiphichaiSIqbalAJet al
Since taking lipoic acid with a meal decreases its bioavailability, it is generally recommended that lipoic acid be taken 30 min prior to a meal (see also Metabolism and Bioavailability) (8)
This is not merely additive: the MOTS-c may amplify or extend the mitochondrial biogenesis signal beyond what training alone achieves, particularly in older adults whose endogenous MOTS-c response to exercise is blunted [2]