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CrossRef Pharmacokinetic profiles, cytotoxicity, and redox metabolism of free and nanoencapsulated curcumin Priscila Marquezan Copetti, Bianca Fagan Bissacotti, Samanta da Silva Gndel, Nathieli Bianchin Bottari, Michele Rorato Sagrillo, Alencar Kolinski Machado, Aline Ferreira Ourique, Maria Rosa Chitolina Schetinger, Aleksandro Schafer da Silva Journal of Drug Delivery Science and Technology.2022
By blocking NNMT activity, it increases critical cellular metabolites (SAM, NAD) that drive downstream increases in energy expenditure and metabolic health 1-4
So people at greatest risk for deficiency include those with low stomach acid (e.g., older adults and people on proton pump inhibitors or antacids) or low IF production (known as pernicious anemia), people on medications that interfere with B12 absorption (such as metformin), people who have had gastric surgery, those with GI conditions that impair nutrient absorption (like celiac or Crohn's disease), and people on vegan and vegetarian diets
Especially, the strong and broad peak at 530.7 eV for pFeSAN indicated its strong ability to adsorb and activate oxygen, which could potentially promote the oxidase-like activity 37
