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On experimental day P38, we measured plasma insulin using the Rat INS ELISA Kit (Mlbio, Shanghai, China) according to the instructions

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Most strikingly, it was found that administration of either MV8608 or MV8612 caused a significant reduction in the nociceptive responses

"That is a much bigger effect than what we would initially anticipate." The research finds that during stress, the sympathetic nervous system over-activates and so depletes the stem cells that make pigment cells