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Pancreatic glucagon is a 29amino acid peptide that regulates glucose homeostasis via gluconeogenesis, glycogenolysis, and lipolysis and is counter regulatory to insulin
doi:10.1016/j.jep.2021.113821 13
Additionally, altered pharmacokinetics could theoretically affect the medication's duration of action, though the clinical significance of this is uncertain given tirzepatide's long half-life
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