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the rate in the placebo-treated group was 3.2 episodes per 100 patient years of exposure
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Users typically report reduction in age spots, melasma, post-inflammatory hyperpigmentation, and general skin dullness within 4-8 weeks of consistent supplementation
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Int J Androl 20:6169
Some of the released molecules, referred to as damage-associated molecular patterns (DAMPs) like heme and its derivatives, ATP, heat shock protein (HSP70), or interleukin-33 (IL-33), are capable of triggering the immune response, amplifying inflammation [62, 63]
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