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As a result, inhibition of xCT by elastin was observed and also the release of glutamate and uptake of cystine were decreased

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expounded on the obesity paradox, suggesting increased BMD is offset by poor bone quality due to advanced glycation end-products (AGEs) accumulation, impaired osteoblast function, and uncoupled bone turnover favoring resorption

Rahman et al

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Animal studies show that tirzepatide distributes to and activates neurons in brain regions involved in regulation of appetite and food intake