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First, this was a retrospective observational study of patient electronic health records, which have inherent limitations in misdiagnosis, overdiagnosis, underdiagnosis, unmeasured or uncontrolled confounders, and biases, so no causal inferences can be drawn

Western blot profiling showed a modest but sustained increase in phosphorylation of S6 kinase and its target S6 with 5FU treatment over time (Fig

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