The paresthesia, particularly tingling in the fingers and hands, is a recognized effect of elevated growth hormone levels and typically resolves as the body adjusts
It works by mimicking the action of a naturally occurring hormone, glucagon-like peptide (GLP-1), which is released by the body after eating
The primary reason is a lack of blood supply
GLP-1 drugs blunt that dopamine response
This is because semaglutide, the active ingredient in Wegovy, can cause kidney problems and a worsening of chronic kidney disease
By stably linking estrogen to GLP-1 in a single molecule, this coagonist can take advantage of estrogen's effects on weight loss while avoiding the negative side effects on other tissues (Finan et al., 2012)