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It occurs naturally in the cells of plants, animals, and humans

Clinical data shows that patients starting at 2.5 mg and advancing to 5 mg or 7.5 mg weekly report higher headache frequency during the jump between doses

[7] [8] While this effect often attenuates over time, it may persist to varying degrees with long-acting agents

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Or their doctor might ask them to lose weight if they have a long-term health condition