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These mechanistic pathways highlight a distinct advantage of microbiome-based interventions: they operate across multiple pathological domains immune signaling, mitochondrial stability, synaptic plasticity, and epigenetic regulation making them inherently multimodal when compared to traditional single-target drugs [163]

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Because Alzheimers disease and dementia risk are closely connected to insulin resistance, vascular health, inflammation, and metabolic dysfunction, researchers are asking whether GLP-1 signaling may influence brain aging

A common concern is weight regain

This randomized, double-blind, placebo-controlled crossover study compared placebo against L-citrulline (2g) + glutathione (200mg)