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21 ConteC.IngrassiaA.BreveJ.BolJ.Timmermans-HuismanE.van DamA.et al (2023)

Endocrinology 152, 31033112

This advice is primarily based on caution due to limited long-term studies on these medications' safety during lactation

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FIGURE 2 In addition to the core subunits that assemble KAR tetramers, native receptors bind to single-pass transmembrane auxiliary subunits, neuropillin and tolloid-like proteins 1/2 (Neto1/2), which modulate their kinetics, polyamine block, enhance biogenesis, trafficking, and promote targeting to the plasma membrane (Zhang et al., 2009