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A 52-week phase 2 trial on AMG133 in people with overweight and obesity is ongoing (NCT05669599)

ghrelin-receptor agonists act at a different receptor on the same cells and additionally suppress somatostatin tone

Bariatric surgery shows more promise for providing weight loss

The medication's effect on gastric emptying can exacerbate pre-existing gastroesophageal reflux disease (GERD), potentially causing retrosternal burning or pressure that mimics cardiac symptoms

Special Considerations for Bariatric and Stomach Procedures If your upcoming surgery involves your stomach or gastrointestinal tractsuch as gastric bypass, gastric sleeve, or endoscopyyour surgical team may recommend stopping semaglutide 5 to 7 days beforehand

Intended Use For laboratory research only