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In mice with hepatocellular carcinoma (HCC), an increased acetate level by fecal-bacterial transplantation or direct administration of acetate inhibited the activity of HDACs, increased acetylation of sex-determining region Y-box transcription factor 13 (Sox13) at site K30, and decreased expression of Sox13, thereby reducing IL-17A production by ILC3s and retarding tumor growth
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In addition, the magnitude of the 1-year mortality reduction observed in GLP-1 RA userslarger than in randomized trialssuggests that residual confounding may persist, including confounding by indication/clinical channeling and a healthy-user effect, and that estimates may be comparator-dependent
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