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The nasal mucosa provides reasonably good peptide absorption, bypassing digestive degradation while offering convenience
Unlike the traditional one drug-one target-one disease paradigm, network-based drug discovery reveals disease mechanisms from a holistic perspective, fully considering the complexity of biological systems [10]
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After Steady State (Weekly Use) With weekly injections, the drug accumulates to steady state over ~45 weeks
This mechanistic hypothesis is supported by clinical data from the SURMOUNT-5 trial, which showed that GI adverse events led to treatment discontinuation less frequently with tirzepatidea dual GIP/GLP-1than with semaglutide, a selective GLP-1RA
Thus, a systematic review of the efficacy of GLP-1RAs in terms of their effect on the underlying pathology of AD and improvement of cognitive functions, which included 6 articles that met the criteria (4 randomized control studies and 2 protocol studies) [53], indicates that GLP-1RA therapy in AD did not alter -amyloid and tau protein biomarkers and did not improve cognitive abilities, but demonstrated potential metabolic and neuroprotective benefits
