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Moreover, TSK can significantly alleviate the pathological changes compared to Benazepril in kidneys of DKD rats, inhibit the expansion of mesangial area and glomerular area (154), significantly downregulate TNF- values, increase SOD levels and reduce MDA levels, which is related to its anti-inflammatory effect and the reduction of oxidative stress levels (151)
Within the db/db mouse model, PCs effectively reduced VSMC proliferation and endothelial cell damage by decreasing MCP-1 and AGEs in mouse serum
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