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Some hypotheses may explain the higher MDA values and the lower GPx activity, pointing to an oxidative stress in our patients: (a) older age (median 12.2 years) (b) a significant change in liver enzymes, malnutrition, and impaired lean mass variables not mentioned in the study by Squadrone et al
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Oncogenic alterations [10, 18,19,20,21] reshape lipid metabolic pathways at the transcriptional and posttranscriptional levels, while microenvironmental cues, such as growth factors, nutrient availability, and metabolic stresses, such as hypoxia further sculpt this metabolic network
