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Ghosh A, Comerota MM, Wan D, Chen F, Propson NE, Hwang SH, Hammock BD, Zheng H

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Using nanocarriers to protect drug cargo while it is in circulation can thus improve API pharmacokinetic and pharmacodynamics profiles

IC50 values (the concentration required to inhibit 50% of enzyme activity) for 5-Amino-1MQ against NNMT are in the low micromolar range (approximately 25 M in published in vitro assays), while IC50 values for structurally related methyltransferases are orders of magnitude higher, suggesting high specificity