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Dans les deux cas, des modifications apportes aux structures des peptides font en sorte que leur biodisponibilit est augmente de faon spectaculaire par rapport aux hormones scrtes naturellement par lintestin, passant de quelques minutes peine plus dune centaine dheures, ce qui permet dadministrer ces mdicaments par injection sous-cutane une seule fois par semaine

These agents exert their effects through distinct yet complementary mechanisms that target key pathways involved in the development and progression of DKD (Fig

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