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H tr gan: Glutathione gip thanh lc c t t gan, ci thin chc nng gan v gip c th khe mnh hn

10.1113/JP282799 87

53 In addition, KRAS and USP1 can also regulate the expression of BCAT2 in PDAC through the ubiquitin-proteasome pathway: KRAS can stabilize the expression of BCAT2 in PDAC by inhibiting the ubiquitination of BCAT2 by spleen tyrosine kinase (SYK) and E3 ubiquitination ligase TRIM21, 54 while USP1 deubiquitinates the K229 site of BCAT2, and BCAAs promote USP1 protein expression at the translation level through the GCN2-eIF2a pathway

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Authors proposed a model wherein PL enters the cell, is hydrolyzed in its active form (hPL) with subsequent formation of a hPL:GSH complex that binds the active site of GSTP1-1 causing its inhibition (Fig