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While human trials are limited, mechanistic research suggests several pathways: Promotes new blood-vessel formation (angiogenesis) and improved micro-circulation in injured tissue

Endogenous IKK shows mainly cytoplasmic localization as it acts as member of the NF-B signaling pathway within the cytoplasm, but a small proportion of IKK is also detectable within the nucleus, likely to exert its NF-B dependent as well as independent functions

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