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For constipation, gradually increase your fiber intake to 2540 grams per day, stay physically active, and drink plenty of water about 72 ounces per day for women and 124 ounces per day for men

This helps ensure that a greater proportion of the weight lost comes from fat, leading to a healthier, leaner body composition

These can be added to smoothies or mixed into foods without significantly changing taste

Ethical/regulatory aspects Given the novelty, informed consent must emphasise off-label / investigational status

Gene expression studies reveal modulation of 408 neuronal genes, including dramatic increases in OPRM1 (opioid receptor, up 1,294%), KCND1 (up 845%), and SLC8A2 (up 737%)

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