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And crucially, what the legal implications are in different contexts

Safety therapeutic relevance: Even well-tolerated compounds require strong efficacy signals to justify continued development

7 Magnesium deficiency or impairment of magnesium-dependent enzymes has been associated with several disease states including hypertension, cardiovascular disease, type 2 diabetes, stroke, seizures, migraine headaches, ADHD, and Alzheimers disease

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Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, et al