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After food intake, the active form of GLP-1 is released into the circulation and activates specific G-protein coupled receptors

GLP-1 medications like Semaglutide (Ozempic, Wegovy) and Tirzepatide (Mounjaro) work by mimicking hormones that regulate appetite and blood sugar

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This is the same mechanism that supports tissue repair, but it is a meaningful contraindication for anyone with active or recent malignancy

Patient experiences in my opinion vary little between semaglutide and tirzepatide, until one gets to high doses where tirzepatide does appear to work slightly better

Lower plasma insulin levels in AK BSO could be due to lower fasting glucose rather than poor insulin secretion [53]